« Make healthy hydration the new norm »

International Society of Nephrology

Since its foundation in 1960, the International Society of Nephrology (ISN) has pursued the worldwide advancement of education, science and patient care in nephrology (the medical sub-specialty dealing with kidneys).

Prof. Louise Moist and Prof Adeera Levin speak about the importance of hydration science for nephrology study

The objectives of the ISN-H4KH Initiative are:

  • To enhance awareness and knowledge on hydration and hydration biomarkers
  • To expand the level of scientific evidence on the effects of hydration on kidney health
  • To engage researchers in the development of transdisciplinary research networks
  • To create sustainable momentum in supporting research in the effect of hydration and kidney health

In this frame, three research opportunities have been created: the ISN-H4KH New Investigator Award, the H4KH Research Grant and the ISN H4KH Research Fellowship. The first call for the ISN-H4KH New investigator Grant and Hydration & Kidney Health Grant was awarded in 2016. As there remains a need to continue to build research capacity and evidence in the field of hydration for kidney health, the ISN and Danone Nutricia Research launched in 2017 a second call for the ISN-H4KH New Investigator Award and the ISN- H4KH Research Grant. In addition, the ISN H4KH Research Fellowship was created in 2017.
More information about the ISN-H4KH grants, winners and their research project is available below.

More information about the ISN-H4KH grants, the winners and their research projects is described below. To know more about the initiative: HERE

As Prof. Louise Moist and Prof. Adeera Levin mentioned in the video below, hydration science is essential for nephrology study. In order to provide access to the state of the art of hydration, the Hydration for Health Academy is embedded in the ISN Education platform since 2019 to.

ISN-H4KH New Investigator Grant:

Applicants will spend up to 12 months working at the Kidney Clinical Research Unit in London, Ontario (Canada). They will gain new skills in clinical research, statistical analysis and begin work on research projects related to hydration for kidney health. In the second year, they will complete their research project and build an infrastructure to support for further research in hydration. The research will then be presented at the World Congress of Nephrology and a paper will be submitted to a peer-reviewed journal.

ISN-H4KH Hydration and Kidney Health Grant:

Grants will be funded to researchers with expertise in and access to:

  • Reliable and valid data in an existing data base
  • Data reflective of a representative sample of the general population and or a population with chronic kidney disease
  • Demographics and comorbidities (Diabetes and hypertension)
  • Serial measure of kidney function

ISN H4KH Research Fellowship

Created in 2017: Applicant will spend 12 months of the year at Danone Nutricia Research, in Palaiseau (Paris) in France to work with the Hydration and Health Department & other scientific networks to expand the level of evidence & awareness on the impact of drinking water and kidney health. Applicant will increase his/her knowledge and understanding on how the science of hydration could be applied in disease prevention and into public health policies.
To know more about the call and applications: http://www.theisn.org/H4KH

H4KH Grant Winner:

New Investigator Grant:

2016: Dr. Fabiana Nerbass

Dr. Fabiana Nerbass

2016: Dr. Fabiana Nerbass, from the Fundação Pró-Rim in Joinville, Brazil received the New Investigator Grant for her project entitled “Kidney health in Brazilian industrial workers exposed to heat stress and dehydration.”

At the end of her training, Dr. Nerbass published a paper entitled “Occupational Heat Stress and Kidney Health: From Farms to Factories” in Kidney International Report. It was the more downloaded report the month following its publication. Read the article here .

Dr. Nerbass explored the effect of heat stress and dehydration on kidney damages in factory workers, she published in 2019 the result of her pilot study entitled “Hydration Status and Kidney Health of Factory Workers Exposed to Heat Stress: A Pilot Feasibility Study”.

The evidence that working condition impairing sufficient water intake is impacting kidney health lead to several broader considerations related to work condition in general. Dr. Nerbass and colleagues discuss this in an article entitled: Can your work affect your kidney’s health?

Dr. Nerbass’s work was shared with a broader community with a media article published in Science Discoveries. Read it here

2018: Dr. Angie Aguilar-González

Dr. Angie Aguilar-González

2018: Dr. Angie Aguilar-González, from FUNDANIER (Fundación par el Niño Enfermo Renal), Guatemala received the 2018 New Investigator Grant for her project entitled “Hydration Patterns and Renal Function Markers in Guatemalan Children and Adolescents in an Area with High Incidence of Renal Disease of Unknown Cause.”

Dr. Angie Aguilar-González spend up to 12 months working at the Kidney Clinical Research Unit in London, Ontario (Canada). She gained new skills in clinical research, statistical analysis and begin work on research projects related to hydration for kidney health. In the second year, she will complete their research project and build an infrastructure to support for further research in hydration.

In 2019, she started her research project in small community in Guatemala, measuring hydration patterns and renal function markers in a group of children and adolescents. To raise awareness among the community and throughout the country, she organized awareness actions such as a “walk for healthy kidney” in May 2019 attended by more than 400 participants. More information about the research project here and the walk here.

ISN-H4KH Hydration and Kidney Health Grant:

2016: Dr. Sofia Enhörning

Dr. Sofia Enhörning

2016: Dr. Sofia Enhörning, from Skåne University Hospital in Malmö, Sweden received the Hydration and Kidney Health Grant for her project entitled "Plasma copeptin as a predictor of, and copeptin associated loci in, cardiorenal disease – population based prospective cohort studies and a mendelian randomization approach.

Following her award, Dr. Enhörning, published 2 papers in peer review journal entitled "Plasma copeptin as a predictor of kidney disease" and " Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones: a water intervention in humans". Read the articles here and here.

2018: Dr. Sandra Wagner

Dr. Sandra Wagner

2018: Dr. Sandra Wagner, from INSERM (Institut national de la santé et de la recherche médicale), France, received the 2018 Hydration and Kidney Health Grant for her project entitled "Association of water intake with osmolarity and renal outcome in patients with CKD stage 3-4. The French CKD-REIN Cohort study".

Dr. Sandra Wagner demonstrated excellence in research into kidney disease and an interest in hydration for kidney health. She also supplied a clear, concise and comprehensive description of their proposed research plan, as this would form an important part of the evaluations process.

ISN H4KH Research Fellowship

Dr. Amarasiri de Silva

2017: Dr. Amarasiri de Silva from University of Pittsburgh was selected for the ISN H4KH Fellowship Program to work with the Hydration, Health and Nutrition Science Department from Danone Nutricia Research and other external scientific networks to expand the level of evidence and awareness on the impact of drinking water and kidney health.

Hydration science is the specialty of the Hydration, Health and Nutrition Science team in France. He says: ‘My visit gave me immense information on the work I am doing as part of my fellowship. I could establish contacts with everyone at Danone Nutricia Research. I was able to introduce the topic of my research to Danone’s scientists.’ Amarasiri De Silva’s research delves into the knowledge, risk factors and perceived symptoms of chronic kidney disease of unknown origin in Sri Lanka. Read Dr. Amarasiri’s article on Drinking water and CKDu in Sri Lanka: HERE

More information on the visit of Dr. Amarasiri de Silva at the research center : HERE